Aminopeptidasas Bacterianas
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2023-06-01
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Jaén: Universidad de Jaén
Resumen
[ES] Las aminopeptidasas bacterianas son exopeptidasas que liberan residuos de
aminoácidos N-terminales de polipéptidos y proteínas de forma selectiva. Estas enzimas
se pueden encontrar en el citoplasma, en las membranas, asociadas a la envoltura celular
o incluso pueden ser secretadas al medio extracelular. En los últimos treinta años se han
realizado diversos estudios acerca del sistema aminopeptídico bacteriano, siendo de
especial interés en futuros campos biotecnológicos. Las aminopeptidasas tienen diversas
aplicaciones tanto terapéuticas como industriales. Estos estudios reflejan que las
aminopeptidasas juegan un papel fundamental en procesos terapéuticos de importancia,
como son el tratamiento de infecciones, la estabilización de péptidos farmacéuticos y la
inhibición bacteriana. Por otro lado, su aplicación en la industria está principalmente
destinada a producir hidrolizados de proteínas, que juegan un papel fundamental en la
industria alimentaria. Estas enzimas son capaces de generar hidrolizados de proteínas no
amargas con propiedades antioxidantes, nutricionales y con funciones mejoradas.
[EN] Bacterial aminopeptidases are exopeptidases that selectively release N-terminal amino acid residues from polypeptides and proteins. These enzymes can be found in the cytoplasm, membranes, associated with the cell envelope or they can even be secreted into the extracellular medium. In the last thirty years, various studies have been carried out on the bacterial aminopeptidase system, being of special interest in future biotechnological fields. Aminopeptidases have various therapeutic and industrial applications. These studies reflect that aminopeptidases play a fundamental role in certain significant therapeutic processes, such as the treatment of infections, stabilization of pharmaceutical peptides and bacterial inhibition. On the other hand, its application in industry is intended mainly to produce protein hydrolysates, which play a fundamental role in the food industry. These enzymes are capable of generating non-bitter protein hydrolysates with antioxidant and nutritional properties and improved functions.
[EN] Bacterial aminopeptidases are exopeptidases that selectively release N-terminal amino acid residues from polypeptides and proteins. These enzymes can be found in the cytoplasm, membranes, associated with the cell envelope or they can even be secreted into the extracellular medium. In the last thirty years, various studies have been carried out on the bacterial aminopeptidase system, being of special interest in future biotechnological fields. Aminopeptidases have various therapeutic and industrial applications. These studies reflect that aminopeptidases play a fundamental role in certain significant therapeutic processes, such as the treatment of infections, stabilization of pharmaceutical peptides and bacterial inhibition. On the other hand, its application in industry is intended mainly to produce protein hydrolysates, which play a fundamental role in the food industry. These enzymes are capable of generating non-bitter protein hydrolysates with antioxidant and nutritional properties and improved functions.