Análisis del papel protector del hidroxitirosol y la oleuropeína aglicona en los procesos de agregación patológica de la alfa-sinucleína
Fecha
2021-07-29
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Jaén: Universidad de Jaén
Resumen
[ES] La enfermedad del Parkinson (EP), es una enfermedad neurodegenerativa causada principalmente por la
falta de dopamina en el cerebro debido a la pérdida de neuronas dopaminérgicas en la sustancia negra del
cerebro.
Aunque la etiología de la EP es probablemente multifactorial, la proteína α-syn se considera el
biomarcador principal de la enfermedad y el proceso de agregación, el mecanismo por el que la α-syn
causa toxicidad y contribuye a la muerte neuronal sigue sin estar claro. Esta revisión discute la evidencia
del papel neuropatológico de la α-syn en la EP, así como el potencial neuroprotector de algunos
polifenoles del olivo, como el Hidroxitirosol (HT) y la Oleuropeína Aglicona (OleA) en esta enfermedad.
Mediante varios estudios a través de diferentes técnicas y modelos experimentales mostramos cómo
estos polifenoles inhiben la formación de agregados de α-syn y contribuyen a la desestabilización de su
estructura patológica.
[EN] Parkinson´s Disease (PD) is a neurodegenerative disease caused mainly by the lack of dopamine in the brain due to the loss of dopaminergic neurons in the substantia nigra of the brain. Although the etiology of PD is likely multifactorial, the α-syn protein is considered the primary biomarker of the disease and the aggregation process, the mechanism by which α-syn causes toxicity and contributes to neuronal death remains unclear. This review discusses the evidence for the neuropathological role of α-syn in PD, as well as the neuroprotective potential of some olive polyphenols, such as Hydroxytyrosol (HT) and Oleuropein Aglycone (OleA) in this disease. By means of several studies through different techniques and experimental models we show how these polyphenols inhibit the formation of α-syn aggregates and contribute to the destabilization of their pathological structure.
[EN] Parkinson´s Disease (PD) is a neurodegenerative disease caused mainly by the lack of dopamine in the brain due to the loss of dopaminergic neurons in the substantia nigra of the brain. Although the etiology of PD is likely multifactorial, the α-syn protein is considered the primary biomarker of the disease and the aggregation process, the mechanism by which α-syn causes toxicity and contributes to neuronal death remains unclear. This review discusses the evidence for the neuropathological role of α-syn in PD, as well as the neuroprotective potential of some olive polyphenols, such as Hydroxytyrosol (HT) and Oleuropein Aglycone (OleA) in this disease. By means of several studies through different techniques and experimental models we show how these polyphenols inhibit the formation of α-syn aggregates and contribute to the destabilization of their pathological structure.