Función de los oxisteroles en el cáncer humano
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2021-07-28
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Jaén: Universidad de Jaén
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[ES] El cáncer es una de las principales causas de mortalidad en el mundo. El desarrollo de esta enfermedad se ha relacionado en ciertas circunstancias con el metabolismo de los oxisteroles. Se ha propuesto que los oxisteroles pueden estar involucrados tanto en procesos de proliferación tumoral como en procesos antiproliferativos a través de la homeostasis del colesterol y de su relación con el sistema inmunitario. Debido a la falta de evidencia científica que relacione los oxisteroles y su papel en la carcinogénesis, el objetivo de este trabajo consistió en recopilar las evidencias científicas existentes del papel que desempeñan los oxisteroles en el cáncer a través de la modulación del sistema inmunitario. En el desarrollo de este trabajo se describen los distintos mecanismos por los que se relaciona a estos metabolitos con el cáncer. Concluimos que los oxisteroles están estrechamente ligados al cáncer y que el conocimiento de sus funciones puede ser la clave para la prevención y cura de esta enfermedad.
[EN] Cancer is one of the leading causes of death in the world. The development of this disease has been related in certain circumstances to the metabolism of oxysterols. It has been proposed that Oxysterols may be involved in both tumour proliferation and antiproliferative processes through cholesterol homeostasis and their relationship with the immune system. Due to the lack of scientific evidence relating to oxysterols and their role in carcinogenesis, this work aimed to find out the scientific evidence of the role of oxysterols in cancer through the modulation of the immune system. In the development of this work, the different mechanisms by which these metabolites are related to cancer are described. The conclusion was that the oxysterols are tightly related to cancer and the knowledge of their functions may be the key to the prevention and cure of this disease.
[EN] Cancer is one of the leading causes of death in the world. The development of this disease has been related in certain circumstances to the metabolism of oxysterols. It has been proposed that Oxysterols may be involved in both tumour proliferation and antiproliferative processes through cholesterol homeostasis and their relationship with the immune system. Due to the lack of scientific evidence relating to oxysterols and their role in carcinogenesis, this work aimed to find out the scientific evidence of the role of oxysterols in cancer through the modulation of the immune system. In the development of this work, the different mechanisms by which these metabolites are related to cancer are described. The conclusion was that the oxysterols are tightly related to cancer and the knowledge of their functions may be the key to the prevention and cure of this disease.