Infecciones nosocomiales por bacterias multirresistentes
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2014-09-15
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Jaén: Universidad de Jaén
Resumen
[ES]Se estima que las infecciones nosocomiales prolongan la estancia hospitalaria
entre 1 y 30 días y se puede cuantificar la mortalidad atribuible entre un 7% y
un 35%. Estas infecciones constituyen un motivo de preocupación para las
instituciones sanitarias a escala mundial, especialmente aquellas causadas por
microorganismos multirresistentes con escasa respuesta a los tratamientos
antimicrobianos empleados habitualmente.
La capacidad de Staphylococcus aureus para adaptarse a presiones selectivas
ha facilitado el desarrollo de resistencia a antimicrobianos y la propagación de
cepas resistentes a meticilina en los ambientes hospitalarios. El presente
proyecto pretende evaluar la incidencia de infecciones nosocomiales asociadas
a Staphylococcus aureus en el centro hospitalario colaborador e identificar los
determinantes genéticos responsables de la resistencia o multirresistencia de
las cepas aisladas. En base a los datos obtenidos se recomendarán al centro
hospitalario pautas de modificación de los tratamientos antimicrobianos
aplicados, de acuerdo con los perfiles de resistencia detectados.
[EN]Hospital-acquired infections often result in longer stays at hospital and they are responsible for about 7% to 35% associated mortality. These infections have traditionally been an important health-related problem and cause of concern all over the world, especially those associated to multi-resistant microorganisms, as they account for low rates of success in antimicrobial therapy. The ability of Staphylococcus aureus to adapt to selective pressures has also facilitated the development of antimicrobial resistance and particularly the spread of methicillin-resistant strains (MRSA) among hospitals. This study has been designed to estimate the prevalence of MRSA among human pathogens causing hospital-acquired infections at the collaborating health center and to identify the genetic determinants responsible for the resistance or multiresistance profiles of the studied strains. According to data obtained from this study, we will provide appropriate guidelines about antibiotic therapy to be used against these resistant pathogens.
[EN]Hospital-acquired infections often result in longer stays at hospital and they are responsible for about 7% to 35% associated mortality. These infections have traditionally been an important health-related problem and cause of concern all over the world, especially those associated to multi-resistant microorganisms, as they account for low rates of success in antimicrobial therapy. The ability of Staphylococcus aureus to adapt to selective pressures has also facilitated the development of antimicrobial resistance and particularly the spread of methicillin-resistant strains (MRSA) among hospitals. This study has been designed to estimate the prevalence of MRSA among human pathogens causing hospital-acquired infections at the collaborating health center and to identify the genetic determinants responsible for the resistance or multiresistance profiles of the studied strains. According to data obtained from this study, we will provide appropriate guidelines about antibiotic therapy to be used against these resistant pathogens.
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Itinerario en biología molecular y clínica