Estudio de la determinación sexual y la diferenciación gonadal en anfibios: análisis comparativo de genes con expresión diferencial en vertebrados
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2016
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Jaén: Universidad de Jaén
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[ES]La decisión entre la ruta de diferenciación masculina o femenina depende de una señal, que puede ser
ambiental o genética, y que se conoce como determinismo del sexo. Esta señal, que es bien conocida en mamíferos, está poco conservada fuera de este grupo. Una estrategia para identificar genes implicados en el desarrollo gonadal consiste en analizar el transcriptoma de
gónadas en desarrollo de ambos sexos e identificar aquellos genes que presenten expresión diferencial, ya que se puede suponer que éstos deben estar implicados en la diferenciación gonadal. En este trabajo se ha analizado un gen candidato obtenido mediante RNAseq, que muestra expresión diferencial en gónadas en desarrollo de Xenopus tropicalis. Este gen, gpc1, se expresa de forma específica de macho en X. tropicalis. El análisis comparativo del patrón de expresión de este gen durante el desarrollo gonadal en Mus musculus, Gallus gallus y X. laevis revela que el patrón de expresión específico de macho se conserva en
vertebrados, si bien muestra algunas diferencias entre especies. Los resultados obtenidos ponen de manifiesto que este gen puede tener un papel importante en la diferenciación gonadal de vertebrados.
[EN]The choice between the male or the female differentiation, pathway depends on a signal that can be environmental or genetic, and is known as sex determinism. This signal, which is well known in mammals, is poorly conserved outside this group. A strategy to identify genes involved in gonadal development is to analyze the transcriptome of developing gonads of both sexes and identify those genes with differential expression, since it can be assumed that they must be involved in gonadal differentiation. In this work a candidate gene obtained by RNAseq with differential expression during gonadal development in Xenopus tropicalis is analyzed. This gene, gpc1, is specifically male-specific in X. tropicalis. The comparative analysis of the expression pattern of this gene during gonadal development in Mus musculus, Gallus gallus and X. laevis reveals that, with some exceptions, the male-specific expression pattern is conserved in vertebrates. The results obtained show that this gene may play a role in vertebrate gonadal differentiation.
[EN]The choice between the male or the female differentiation, pathway depends on a signal that can be environmental or genetic, and is known as sex determinism. This signal, which is well known in mammals, is poorly conserved outside this group. A strategy to identify genes involved in gonadal development is to analyze the transcriptome of developing gonads of both sexes and identify those genes with differential expression, since it can be assumed that they must be involved in gonadal differentiation. In this work a candidate gene obtained by RNAseq with differential expression during gonadal development in Xenopus tropicalis is analyzed. This gene, gpc1, is specifically male-specific in X. tropicalis. The comparative analysis of the expression pattern of this gene during gonadal development in Mus musculus, Gallus gallus and X. laevis reveals that, with some exceptions, the male-specific expression pattern is conserved in vertebrates. The results obtained show that this gene may play a role in vertebrate gonadal differentiation.
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Biología molecular y clínica