ESTUDIO DE ALTERACIONES DE LA REPRODUCCIÓN MEDIANTE ANÁLISIS INFORMACIONAL Y DE ESTRUCTURA DE REDES.
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2020-10-13
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Jaén: Universidad de Jaén
Resumen
La endometriosis es un trastorno ginecológico que se caracteriza por la presencia de tejido endometrial en ubicaciones
extrauterinas. Esta afección tiene una alta prevalencia en mujeres en edad reproductiva puesto que es dependiente de
estrógenos. La etiología y la patogénesis de esta enfermedad sigue siendo incierta. En este Trabajo de Fin de Grado se ha
estudiado la genética de la endometriosis desde el enfoque global de la Biología de Sistemas, mediante la realización de un
análisis bibliométrico y el estudio de redes biológicas. Tras la realización de este estudio se vio que las proteínas implicadas en
este proceso estaban relacionadas con: proliferación, apoptosis, adhesión e invasión, angiogénesis y alteración de la función
inmune. Asimismo, se identificaron los genes más relevantes, todos ellos relacionados con la carcinogénesis. En definitiva, esto
nos da una idea de los eventos moleculares que contribuyen al desarrollo de esta enfermedad.
Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue in extrauterine locations. The disease has a high prevalence in reproductive age women given that it is dependent on estrogens. The etiology and pathogenesis of this disease remain uncertain. In this work, the genetics of endometriosis has been studied from the global approach of Systems Biology, by means of a bibliometric analysis and the study of biological networks. After carrying out this study, it was found that the proteins involved in this process were related to: proliferation, apoptosis, adhesion and invasion, angiogenesis and alteration of immune function. Additionally, the most relevant genes were identified, all of them related to carcinogenesis. In conclusion, this gives us an idea of the molecular events that contribute to the development of this disease.
Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue in extrauterine locations. The disease has a high prevalence in reproductive age women given that it is dependent on estrogens. The etiology and pathogenesis of this disease remain uncertain. In this work, the genetics of endometriosis has been studied from the global approach of Systems Biology, by means of a bibliometric analysis and the study of biological networks. After carrying out this study, it was found that the proteins involved in this process were related to: proliferation, apoptosis, adhesion and invasion, angiogenesis and alteration of immune function. Additionally, the most relevant genes were identified, all of them related to carcinogenesis. In conclusion, this gives us an idea of the molecular events that contribute to the development of this disease.