BIOQUÍMICA DEL Ca2+ Y SU FUNCIÓN COMO MENSAJERO INTRACELULAR.
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2020-10-19
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Jaén: Universidad de Jaén
Resumen
El calcio es un ión muy versátil con multitud de funciones en el organismo, cuyo objetivo es mantener la homeostasis, además de considerarse como segundo mensajero. El calcio lo podemos encontrar unido a diversas proteínas como la albúmina, o bien disuelto en el plasma, donde se encuentra en su mayor proporción en forma de ión. La señalización celular se produce gracias a una multitud de proteínas implicadas en el transporte y almacenamiento a los diferentes reservorios de este ión, entre las que cabe destacar los receptores IP3 y los receptores rianodina. La mayoría de las proteínas que tienen afinidad por el calcio tienen la particularidad de formar parte de las proteínas, entre las que destacan la calmodulina, anexinas, y proteínas quinasas. Finalmente destacar los procesos celulares que dependen del calcio, éste participa en la contracción muscular, en la transmisión nerviosa, en la regulación enzimática, así como en procesos de coagulación.
Calcium is a very versatile ion with many functions in the body, whose objective is to maintain homeostasis, in addition to being considered as a second messenger. Calcium can be found together with various proteins such as albumin, or dissolved in plasma, where it is found in its largest proportion in the form of an ion. Cellular signaling occurs thanks to a multitude of proteins involved in the transport and storage of the different reservoirs of this ion, among which the IP3 receptors and the ryanodine receptors are worth noting. Most of the proteins that have an affinity for calcium have the particularity of being part of the proteins, among which calmodulin, annexins, and protein kinases stand out. Finally highlight the cellular processes that depend on calcium, it participates in muscle contraction, nerve transmission, enzyme regulation, as well as coagulation processes.
Calcium is a very versatile ion with many functions in the body, whose objective is to maintain homeostasis, in addition to being considered as a second messenger. Calcium can be found together with various proteins such as albumin, or dissolved in plasma, where it is found in its largest proportion in the form of an ion. Cellular signaling occurs thanks to a multitude of proteins involved in the transport and storage of the different reservoirs of this ion, among which the IP3 receptors and the ryanodine receptors are worth noting. Most of the proteins that have an affinity for calcium have the particularity of being part of the proteins, among which calmodulin, annexins, and protein kinases stand out. Finally highlight the cellular processes that depend on calcium, it participates in muscle contraction, nerve transmission, enzyme regulation, as well as coagulation processes.