Medición de marcadores de placentación en primer trimestre del embarazo y su relación con el desarrollo de diabetes mellitus gestacional
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2016
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Jaén: Universidad de Jaén
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[ES]En este trabajo se examinaron los niveles sanguíneos de HbA1c, AU, PAPP-A, β-hCGl, NO
y TBARS en el primer trimestre de gestación de mujeres afectadas con DMG. En el presente estudio prospectivo de cohorte de 3546 mujeres embarazadas, las muestras de sangre fueron recogidas entre la semana 9-13 de gestación durante el análisis de viabilidad fetal. Se utilizó la prueba de Mann-Whitney para determinar la diferencia significativa entre grupos. El rendimiento de la detección se determinó mediante el análisis de curvas ROC. En las mujeres que desarrollaron posteriormente DMG, la mediana de MoM de β-hCGl fue menor (p=0.017) que en los controles. El análisis porcentual de MoM de β-hCGl encontró significación estadística en los niveles por debajo del percentil 30. Las medias de HbA1c fueron mayores en el grupo con DMG (p=0.042). Las medias de PAPPA-A y TBARS fueron menores (p=0.009; p=0.003 respectivamente). Los MoM de β-hCGl, HbA1c y AU pueden ser marcadores útiles en el embarazo temprano para predecir el desarrollo de DMG.
[EN]This work analyse the level of HbA1c, AU, PAPP-A, β-hCGl, NO and TBARS in the first trimester of pregnancy in women developing DMG. In the present large obervational cohort study of 3546 pregnant women, blood samples were collected once from each participant at 9th-13th weeks of gestation during the fetal viatility scan. Mann-Whitney test was used to determine the significance of difference between groups. The performance of screening was determined by receiver-operating characteristic (ROC) curves. In women who later develop GDM the average β-hCGl value (MoM) was lower (p=0.017) than in the controls. Percentile analysis of β-hCGl MoM found statistical significance in levels ≤ of percentile 30. HbA1c was higher in GDM group (p=0.042), whereas PAPP-A and TBARS were lower (p=0.009 and p=0.003, respectively). β-hCGl MoM, HbA1c and UA may be useful biomarkers in early pregnancy to predict the development of GDM.
[EN]This work analyse the level of HbA1c, AU, PAPP-A, β-hCGl, NO and TBARS in the first trimester of pregnancy in women developing DMG. In the present large obervational cohort study of 3546 pregnant women, blood samples were collected once from each participant at 9th-13th weeks of gestation during the fetal viatility scan. Mann-Whitney test was used to determine the significance of difference between groups. The performance of screening was determined by receiver-operating characteristic (ROC) curves. In women who later develop GDM the average β-hCGl value (MoM) was lower (p=0.017) than in the controls. Percentile analysis of β-hCGl MoM found statistical significance in levels ≤ of percentile 30. HbA1c was higher in GDM group (p=0.042), whereas PAPP-A and TBARS were lower (p=0.009 and p=0.003, respectively). β-hCGl MoM, HbA1c and UA may be useful biomarkers in early pregnancy to predict the development of GDM.