Pirrolisina: el 22º aminoácido proteinogénico
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2022-07-12
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Jaén: Universidad de Jaén
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[ES] La pirrolisina es un aminoácido descubierto recientemente y se conoce como el 22º aminoácido proteinogénico. En el presente trabajo, mencionaremos los diferentes dominios (Bacteria, Eukarya y Archaea) y se discutirá la presencia de la pirrolisina en bacterias y arqueas metanógenas (productoras de metano). El objetivo principal es analizar el papel de la pirrolisina en algunas proteínas implicadas en el metabolismo metanogénico de estos organismos, haciendo especial énfasis en el proceso de síntesis de pirrolisina, y en el mecanismo de incorporación de pirrolisina a las proteínas, utilizando un mecanismo que difiere al de los otros aminoácidos proteinogénicos, ya que precisa de la participación de genes específicos: genes pyl, un aminoacil tRNA específico con su codón correspondiente UAG, y una posible secuencia PYLIS en el mARN para la incorporación de la pirrolisina en la secuencia peptídica.
[EN] Pyrrolysine is a recently discovered amino acid and is known as the 22nd proteinogenic amino acid. In the present work, we will mention the different domains (Bacteria, Eukarya and Archaea) and discuss the presence of pyrrolysine in methanogenic (methane-producing) bacteria and archaea. The main objective is to analyse the role of pyrrolysine in some proteins involved in the methanogenic metabolism of these organisms, with special emphasis on the process of pyrrolysine synthesis, and on the mechanism of pyrrolysine incorporation into proteins, using a mechanism that differs from that of the other proteinogenic amino acids, as it requires the participation of specific genes: pyl genes, a specific aminoacyl tRNA with its corresponding UAG codon, and a possible PYLIS sequence in the mRNA for the incorporation of pyrrolysine into the peptide sequence.
[EN] Pyrrolysine is a recently discovered amino acid and is known as the 22nd proteinogenic amino acid. In the present work, we will mention the different domains (Bacteria, Eukarya and Archaea) and discuss the presence of pyrrolysine in methanogenic (methane-producing) bacteria and archaea. The main objective is to analyse the role of pyrrolysine in some proteins involved in the methanogenic metabolism of these organisms, with special emphasis on the process of pyrrolysine synthesis, and on the mechanism of pyrrolysine incorporation into proteins, using a mechanism that differs from that of the other proteinogenic amino acids, as it requires the participation of specific genes: pyl genes, a specific aminoacyl tRNA with its corresponding UAG codon, and a possible PYLIS sequence in the mRNA for the incorporation of pyrrolysine into the peptide sequence.