Obesidad y Sistema-Renina-Angiotensina
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Fecha
2023-05-31
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Jaén: Universidad de Jaén
Resumen
[ES] Este trabajo aborda la relación entre hipertensión, obesidad y el sistema renina-angiotensina-
aldosterona (RAAS). Se utilizó las bases de datos PubMed y Web of Science (WOS) para realizar búsquedas
bibliográficas sobre el tema. Se encontró que el RAAS desempeña un papel importante en la patología de
la obesidad y la hipertensión, tanto a nivel sistémico como local en los tejidos adiposos, en modelos
animales. En modelos humanos, se sugiere que la activación excesiva del RAAS podría ser un factor en el
desarrollo de hipertensión en personas obesas. Sin embargo, se encontró que la Angiotensina 1-7 (Ang 1-
7) tiene efectos beneficiosos en el metabolismo, la función endotelial y la presión arterial en el contexto
de la obesidad. Además, se observó una conexión genética entre el sistema renina-angiotensina y la
obesidad, respaldada por diversos estudios.
[EN] This work focuses on the relationship between hypertension, obesity, and the renin-angiotensin- aldosterone system (RAAS). Through extensive research using PubMed and Web of Science (WOS) databases, the study highlights the significant role of the RAAS in the development of obesity and hypertension in both animal and human models. The excessive activation of the RAAS is believed to contribute to hypertension in obese individuals. However, it has been found that Angiotensin 1-7 (Ang 1- 7) within the RAAS pathway has beneficial effects on metabolism, endothelial function, and blood pressure in the context of obesity. Additionally, genetic determinants of the Renin-Angiotensin System (RAS) have been observed, providing further evidence of the connection between RAS, obesity, and its associated complications.
[EN] This work focuses on the relationship between hypertension, obesity, and the renin-angiotensin- aldosterone system (RAAS). Through extensive research using PubMed and Web of Science (WOS) databases, the study highlights the significant role of the RAAS in the development of obesity and hypertension in both animal and human models. The excessive activation of the RAAS is believed to contribute to hypertension in obese individuals. However, it has been found that Angiotensin 1-7 (Ang 1- 7) within the RAAS pathway has beneficial effects on metabolism, endothelial function, and blood pressure in the context of obesity. Additionally, genetic determinants of the Renin-Angiotensin System (RAS) have been observed, providing further evidence of the connection between RAS, obesity, and its associated complications.