Síntesis de derivados de 4-Amino-6-Benciloxi-5- Nitrosopirimidina
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2016-02-19
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Jaén: Universidad de Jaén
Resumen
La lucha bacteriológica a menudo obliga a recurrir a nuevos tipos de compuestos que combatan a diferentes tipos de patógenos que estén o se hayan conseguido inmunizar frente a los precursores de los nuevos antibacterianos. Es por ello que la síntesis de este tipo de compuestos a menudo resulta indispensable para la salud pública. En este trabajo se pretende sintetizar una serie de derivados, a los cuales se les conoce que poseen propiedades antibacterianas, con el objetivo de comprobar si la incorporación de una serie de nuevos grupos funcionales mejoran las propiedades antisépticas que poseen. Para la síntesis de estos compuestos con base pirimidínica se pretende realizar un estudio a través de diferentes medios de reacción con el fin de comprobar cómo mejorar el rendimiento de la reacción y conocer en qué proporción se encuentra un isómero frente al otro. Por último se llevará a cabo la caracterización de los derivados pirimidínicos sintetizados mediante diferentes técnicas espectroscópicas (RMN, IR, MS, UV-Vis).
The bacteriological dispute often obliges to resort to new types of compounds which fight different types of bacteria immunized against the new antibacterial forefathers. Therefore, the synthesis of these types of compounds normally turns out essential for the public health. In this work, a series of derivatives are expected to be synthesized. These derivatives are known for having antibacterial properties. The objective is to check whether the incorporation of a series of new functional groups improves the antiseptic properties they have. For the synthesis of these compounds which have a pyrimidinic ring, it will be made a study through different means of reaction with the purpose of testing how to improve the yield of the reaction and also to know the ratio of each isomer. Finally, it will be carried out the characterization of the pyrimidinic derivatives synthesized through different spectrometric techniques (NMR, IR, MS, UV-Vis).
The bacteriological dispute often obliges to resort to new types of compounds which fight different types of bacteria immunized against the new antibacterial forefathers. Therefore, the synthesis of these types of compounds normally turns out essential for the public health. In this work, a series of derivatives are expected to be synthesized. These derivatives are known for having antibacterial properties. The objective is to check whether the incorporation of a series of new functional groups improves the antiseptic properties they have. For the synthesis of these compounds which have a pyrimidinic ring, it will be made a study through different means of reaction with the purpose of testing how to improve the yield of the reaction and also to know the ratio of each isomer. Finally, it will be carried out the characterization of the pyrimidinic derivatives synthesized through different spectrometric techniques (NMR, IR, MS, UV-Vis).