EFECTO DE LA ADMINISTRACIÓN DE PREBIÓTICOS EN EL DESARROLLO DE DIABETES TIPO 1: INTEGRIDAD DEL COLON.
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2020-10-14
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Jaén: Universidad de Jaén
Resumen
La diabetes tipo 1 (DM1) es una enfermedad crónica autoinmune caracterizada por la destrucción de las células β pancreáticas productoras de insulina. Aunque existe una fuerte predisposición genética, factores ambientales tales como el tipo de parto, la dieta y el uso temprano de antibióticos, juegan también un papel importante en su desarrollo. Estos factores pueden modificar la microbiota del intestino grueso y llegar a alterar la integridad y permeabilidad del mismo, permitiendo una mayor exposición del sistema inmunitario intestinal a los antígenos, lo que favorecería el inicio y progresión de la diabetes. La utilización de determinados compuestos en la dieta, como los prebióticos, puede proteger el desarrollo de la DM1 al regular la respuesta inmune. Considerando estos antecedentes, el objetivo principal de este proyecto es estudiar el efecto protector de la administración temprana de oligosacáridos de la leche humana en un modelo animal de DM1, analizando la microbiota intestinal y la integridad de la pared del colon de forma comparada en animales pre-diabéticos y diabéticos.
Type 1 diabetes (DM1) is a chronic autoimmune disease characterized by the destruction of insulin-producing cells from pancreatic islets. Although there is a strong genetic predisposition, environmental factors, such as the type of delivery, the diet and an early use of antibiotics, can play an important role in its development as well. These factors can modify the microbiota of the large intestine and can also alter its integrity and permeability, allowing a greater exposure of the intestinal immune system to antigens, which would promote the onset and progression of diabetes. The use of certain compounds in the diet, such as prebiotics, can protect from the development of DM1 by regulating the immune response. Considering this background, the main objective of this project is to study the protective effect of early administration of oligosaccharides of human milk in an animal model of DM1, analyzing the gut microbiota and the integrity of the colon wall in pre-diabetic and diabetic animals.
Type 1 diabetes (DM1) is a chronic autoimmune disease characterized by the destruction of insulin-producing cells from pancreatic islets. Although there is a strong genetic predisposition, environmental factors, such as the type of delivery, the diet and an early use of antibiotics, can play an important role in its development as well. These factors can modify the microbiota of the large intestine and can also alter its integrity and permeability, allowing a greater exposure of the intestinal immune system to antigens, which would promote the onset and progression of diabetes. The use of certain compounds in the diet, such as prebiotics, can protect from the development of DM1 by regulating the immune response. Considering this background, the main objective of this project is to study the protective effect of early administration of oligosaccharides of human milk in an animal model of DM1, analyzing the gut microbiota and the integrity of the colon wall in pre-diabetic and diabetic animals.