Dietas altas en fructosa y regulación de la presión arterial. Efectos sobre el sistema Remina-Angiotensina sistémico
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2017-10-31
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Jaén: Universidad de Jaén
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[ES]El incremento del consumo de azúcares con la dieta se ha vinculado directamente con la incidencia de enfermedades cardiovasculares crónicas. La ingesta alta en fructosa está relacionada con el aumento de la presión arterial en modelos animales, siendo el Sistema Renina-Angiotensina sistémico el responsable de su mantenimiento a largo plazo. En este estudio, se analiza si una dieta suplementada con un 10% de fructosa durante 8 semanas contribuye al aumento de la presión arterial y el desarrollo de hipertrofia cardíaca en ratas Wistar, determinando su posible relación con alteraciones en el metabolismo de angiotensinas sistémicas, a través de ciertas actividades aminopeptidasas (AlaAP, CysAP y GluAP) del plasma sanguíneo. Los resultados, aunque no alcanzan la significación, parecen indicar que una dieta rica en fructosa tiende a producir hipertensión arterial, estimulando las actividades aminopeptidasas del Sistema Renina-Angiotensina sistémico. Además, produce un aumento del peso del corazón, lo que indica una hipertrofia cardíaca.
[EN]The increase in sugar consumption with the diet has linked directly to the incidence of chronic cardiovascular diseases. The high fructose intake is associated with increased blood pressure in animal models, being the systemic Renin-Angiotensin System responsible for its long-term regulation. In this study, it's analyzed if the intake of a diet supplemented with 10% fructose during 8 weeks, it contributes to the increase of blood pressure and the development of hypertrophy cardiac in Wistar rats, and its relation to changes in the metabolism of systemic angiotensins," through of aminopeptidases activities (AlaAP, CysAP and GluAP) in plasma. The results, although they don't reach significance, indicate that a diet rich in fructose tends to produce an increase in arterial blood pressure and the upregulating of the aminopeptidases activities implicated in the systemic Renin-Angiotensin System. In addition, it causes an increase in the weight of the heart, which indicates a cardiac hypertrophy.
[EN]The increase in sugar consumption with the diet has linked directly to the incidence of chronic cardiovascular diseases. The high fructose intake is associated with increased blood pressure in animal models, being the systemic Renin-Angiotensin System responsible for its long-term regulation. In this study, it's analyzed if the intake of a diet supplemented with 10% fructose during 8 weeks, it contributes to the increase of blood pressure and the development of hypertrophy cardiac in Wistar rats, and its relation to changes in the metabolism of systemic angiotensins," through of aminopeptidases activities (AlaAP, CysAP and GluAP) in plasma. The results, although they don't reach significance, indicate that a diet rich in fructose tends to produce an increase in arterial blood pressure and the upregulating of the aminopeptidases activities implicated in the systemic Renin-Angiotensin System. In addition, it causes an increase in the weight of the heart, which indicates a cardiac hypertrophy.