Efecto Warburg
Archivos
NO SE HA AUTORIZADO la consulta de los documentos asociados
Fecha
2019-06-15
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Jaén: Universidad de Jaén
Resumen
[ES] El efecto Warburg definido como la adaptación metabólica experimentada por las células tumorales, se basa en la utilización de la glucólisis aeróbica como fuente de energía. A pesar de que su descripción tuvo lugar a comienzos del siglo XX, el interés por este efecto ha resurgido con fuerza en los últimos años. Con estos antecedentes, en este Trabajo Fin de Grado se ha pretendido realizar una revisión bibliográfica en la que, partiendo del conocimiento general de la glucólisis, se ponga de manifiesto: las isoenzimas concretas que sustentan esta adaptación metabólica, los mecanismos moleculares responsables de su expresión y actividad, así como el significado biológico que este efecto tiene. La revisión termina destacando su utilidad diagnóstica y terapéutica, un campo en el que se ha avanzado mucho en los últimos años y que está permitiendo el desarrollo nuevas estrategias terapéuticas antitumorales.
[EN] The Warburg effect, a metabolic adaptation that occurs in tumor cells, consists on the use of aerobic glycolysis as the main source of energy. Although its description took place at the beginning of the 20th century, it has been extensively investigated in recent years. With this background, the aim of this Final Degree Project has been to perform a bibliographic review in which, starting from a general víew of the glycolysis, we have deepened into the specific isoenzymes that support this metabolic adaptation, the molecular mechanisms responsible for its expression and activity, and the biological significance of this effect. The review ends by highlighting its diagnostic and therapeutic relevance, a field in which much progress has been recently made and that is allowing the development of promising antitumor strategies.
[EN] The Warburg effect, a metabolic adaptation that occurs in tumor cells, consists on the use of aerobic glycolysis as the main source of energy. Although its description took place at the beginning of the 20th century, it has been extensively investigated in recent years. With this background, the aim of this Final Degree Project has been to perform a bibliographic review in which, starting from a general víew of the glycolysis, we have deepened into the specific isoenzymes that support this metabolic adaptation, the molecular mechanisms responsible for its expression and activity, and the biological significance of this effect. The review ends by highlighting its diagnostic and therapeutic relevance, a field in which much progress has been recently made and that is allowing the development of promising antitumor strategies.