Evaluación de parámetros de estrés oxidativo en mujeres sanas pre- y postmenopáusicas y en mujeres con cáncer de mama tratadas o no con quimioterapia neoadyuvante
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2014-09-15
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Jaén: Universidad de Jaén
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[ES]Se analiza el estado redox en mujeres sanas y en mujeres con cáncer de mama pre- y postmenopáusicas para evaluar
las consecuencias de las alteraciones hormonales de la menopausia en relación con el estrés oxidativo, las
modificaciones con el cáncer de mama, y la influencia de la quimioterapia neoadyuvante. Para ello se han medido en
el suero parámetros de estrés oxidativo, sistemas de defensa antioxidantes no enzimáticos y enzimáticos. La
menopausia modifica el estado redox en mujeres sanas y en mujeres con cáncer de mama. También, la
quimioterapia neoadyuvante incrementa el daño oxidativo, disminuye las defensas antioxidantes y elimina las
diferencias encontradas con la menopausia. Se concluye que el cáncer de mama altera el equilibrio redox normal,
pero también se ve afectado por el estado hormonal promovido por la menopausia. La quimioterapia neoadyuvante
anula las diferencias encontradas entre las mujeres pre- y postmenopáusicas en varios sistemas de defensa
antioxidante.
[EN]We evalúate the redox status in pre- and post-menopausal healthy women and ín women with breast cáncer ¡n order to understand the consequences of the hormonal alterations of menopause for the oxidative stress status, its modifications wíth breast cáncer and the ínfluence of neoadjuvant chemotherapy. To that, serum oxidative stress parameters, non-enzyme and enzyme antioxidant defenses were measured. We found that menopause itself modifies the redox status of healthy women, being most of these differences also reflected in women with breast cáncer. Furthermore, neoadjuvant chemotherapy increases oxidative damage, decreases antioxidant defenses and eliminates the differences found in menopause. We conclude that the normal redox balance is disrupted by breast cáncer but is also affected by the hormonal status promoted by menopause. In fact, NC nullifíes the differences found between pre- and postmenopausal women ¡n several antioxidant defense systems.
[EN]We evalúate the redox status in pre- and post-menopausal healthy women and ín women with breast cáncer ¡n order to understand the consequences of the hormonal alterations of menopause for the oxidative stress status, its modifications wíth breast cáncer and the ínfluence of neoadjuvant chemotherapy. To that, serum oxidative stress parameters, non-enzyme and enzyme antioxidant defenses were measured. We found that menopause itself modifies the redox status of healthy women, being most of these differences also reflected in women with breast cáncer. Furthermore, neoadjuvant chemotherapy increases oxidative damage, decreases antioxidant defenses and eliminates the differences found in menopause. We conclude that the normal redox balance is disrupted by breast cáncer but is also affected by the hormonal status promoted by menopause. In fact, NC nullifíes the differences found between pre- and postmenopausal women ¡n several antioxidant defense systems.