Dietas altas en fructosa. Efectos sobre el peso corporal y la glucemia
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2017-10-31
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Jaén: Universidad de Jaén
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[ES]La ingesta de fructosa en la dieta ha aumentado dramáticamente en los últimos años. Este aumento en laingesta de azúcares simples se ha relacionado con la incidencia de diferentes enfermedades crónicas como la obesidad y la diabetes tipo 2. Sin embargo, los mecanismos moleculares de estos efectos siguen siendo poco claros. Varias peptidasas han sido implicadas en el metabolismo de péptidos bioactivos en el tejido adiposo. Lasangiotensinasas, principalmente Aminopeptidasa A (GlutamilAminopeptidasa) y Aminopeptidasa M (Alanil Aminopeptidasa) participan en el metabolismo de las angiotensinas (Angll, Anglll y AnglV) implicadas en el metabolismo y diferenciación de los adipocitos. El enzima DipeptidilPeptidasa IV (DPPIV) está relacionado con el metabolismo del GLP-1, una potente hormona insulinotrópica que regula el metabolismo de la glucosa. En este trabajo se analizaron los efectos de una dieta enriquecida en fructosa sobre la actividad deAlanina Aminopeptidasa y DPPIV en la grasa visceral de ratas Wistar machos y hembras, y la posible relación con otros factores implicados en el desarrollo de la obesidad y el síndrome metabólico.
[EN]The intake of fructose in the diet has risen dramatically in the last years. This increase in the intake of simple sugars has been related to the incidence of different chronic diseases such as obesity and type 2 diabetes. However, the molecular mechanisms of these effects remain unclear. Several peptidases have been implicated in the metabolism of bioactive peptides in the adipose tissue. Angiotensinases, mainly Aminopeptidase A (Glutamyl Aminopeptidase) and Aminopeptidase M (Alanyl Aminopeptidase) take part in the metabolism of angiotensines (AngII, AngIII and AngIV) involved in the metabolism and differentiation of adipocytes. Dipeptidyl Peptidase IV (DPPIV) is related to the metabolism of GLP-1, a potent insulinotropic hormone that regulates the glucose metabolism. In this work, we have analyzed the effects of a diet enriched in fructose on the activity of Alanyl Aminopeptidase and DPPIV in visceral fat of male and female Wistar rats, and the relationship with others factor implicated in the development of obesity and metabolic syndrome.
[EN]The intake of fructose in the diet has risen dramatically in the last years. This increase in the intake of simple sugars has been related to the incidence of different chronic diseases such as obesity and type 2 diabetes. However, the molecular mechanisms of these effects remain unclear. Several peptidases have been implicated in the metabolism of bioactive peptides in the adipose tissue. Angiotensinases, mainly Aminopeptidase A (Glutamyl Aminopeptidase) and Aminopeptidase M (Alanyl Aminopeptidase) take part in the metabolism of angiotensines (AngII, AngIII and AngIV) involved in the metabolism and differentiation of adipocytes. Dipeptidyl Peptidase IV (DPPIV) is related to the metabolism of GLP-1, a potent insulinotropic hormone that regulates the glucose metabolism. In this work, we have analyzed the effects of a diet enriched in fructose on the activity of Alanyl Aminopeptidase and DPPIV in visceral fat of male and female Wistar rats, and the relationship with others factor implicated in the development of obesity and metabolic syndrome.