MICROBIOTA INTESTINAL Y COVID-19
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2022-03-08
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Jaén: Universidad de Jaén
Resumen
[ES] A finales de 2019 se detectó un brote de neumonía en la ciudad de China de Wuhan, identificándose, posteriormente, que se trataba de una enfermedad producida por un nuevo agente infeccioso, el virus del síndrome respiratorio agudo severo 2 (SARS-CoV-2), y que se denominó “COronaVirus Infectious Disease 2019” (COVID-19). Los síntomas más comunes en las personas afectadas eran la tos, la dificultad para respirar y la fiebre entre otros síntomas típicos respiratorios, pero también eran evidentes los síntomas gastrointestinales en los pacientes más graves de la enfermedad, normalmente aquellos que se encontraban en la Unidad de Cuidados Intensivos, entre los que destacaban la diarrea, las náuseas o la colitis ulcerosa. En estos pacientes se identificó la existencia de disbiosis intestinal, una afección que puede acarrear otros efectos negativos, ya que la microbiota está involucrada en la regulación de diversas funciones en el organismo, entre las que destaca la regulación del sistema inmunológico, y cuya regulación se ha visto comprometida en esta enfermedad. Esto es así ya que muchas de las muertes causadas por el SARS-CoV-2 se sospechan que han sido causadas por la “tormenta de citoquinas”, una respuesta inmunitaria exagerada. Estos datos indican que existe una relación entre la nueva enfermedad
COVID-19 y la microbiota intestinal.
[EN] At the end of 2019, an outbreak of pneumonia was detected in the Chinese city of Wuhan, subsequently identified as a disease caused by a new infectious agent, the severe acute respiratory síndrome coronavirus 2 (SARS-CoV-2), and called “COronaVirus Infectious Disease” 2019 (COVID-19). The most common symptoms in the affected persons were cough, difficulty breathing and fever among other typical respiratory symptoms, but gastrointestinal symptoms were also evident in the most severe patients with the disease, usually those in the Intensive Care Unit, among which diarrhea, nausea or ulcerative colitis stood out. In these patients, the existence of intestinal dysbiosis was identified, a condition that can have other negative effects, since the microbiota is involved in the regulation of various functions in the body, including the regulation of the immune system, and whose regulation has been compromised in this disease. This is because many of the deaths caused by SARS-CoV-2 are suspected to have been caused by the "cytokine storm", an exaggerated immune response. These data indicate a link between the novel disease COVID-19 and the gut microbiota.
[EN] At the end of 2019, an outbreak of pneumonia was detected in the Chinese city of Wuhan, subsequently identified as a disease caused by a new infectious agent, the severe acute respiratory síndrome coronavirus 2 (SARS-CoV-2), and called “COronaVirus Infectious Disease” 2019 (COVID-19). The most common symptoms in the affected persons were cough, difficulty breathing and fever among other typical respiratory symptoms, but gastrointestinal symptoms were also evident in the most severe patients with the disease, usually those in the Intensive Care Unit, among which diarrhea, nausea or ulcerative colitis stood out. In these patients, the existence of intestinal dysbiosis was identified, a condition that can have other negative effects, since the microbiota is involved in the regulation of various functions in the body, including the regulation of the immune system, and whose regulation has been compromised in this disease. This is because many of the deaths caused by SARS-CoV-2 are suspected to have been caused by the "cytokine storm", an exaggerated immune response. These data indicate a link between the novel disease COVID-19 and the gut microbiota.