La mitocondria, orgánulo celular implicado en la etiopatogenia de la fibromialgia
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2021-07-28
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Jaén: Universidad de Jaén
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[ES] La mitocondria es un orgánulo de la célula eucariota, encargada de la producción de energía y mantenimiento de la homeostasis celular. Sin embargo, investigaciones realizadas durante los últimos veinte años relacionan a este orgánulo con situaciones de desorden celular y enfermedad. La Fibromialgia es una enfermedad compleja de etiopatogenia no definida. Uno de los factores relacionados con su desarrollo es el estrés oxidativo. El presente Trabajo Fin de Grado, ha revisado las principales investigaciones llevadas a cabo en los últimos veinte años y que relacionan la disfunción mitocondrial y el estrés oxidativo con la etiopatogenia de la FM. A pesar de la clara evidencia de esta relación, se constata la necesidad de seguir avanzando en este campo y aspirar, en un futuro próximo, al diseño y desarrollo de tratamientos específicos y efectivos para abordar la enfermedad.
[EN] The mitochondrion is an organelle of the eukaryotic cell, responsible for energy production and maintenance of cellular homeostasis. However, research carried out over the last twenty years has linked this organelle to situations of cellular disorder and disease. Fibromyalgia is a complex disease of undefined aetiopathogenesis. One of the factors related to its development is oxidative stress. This Final Degree Project has reviewed the main research carried out in the last twenty years that relates mitochondrial dysfunction and oxidative stress to the aetiopathogenesis of FM. Despite the clear evidence of this relationship, there is a need to continue advancing in this field and to aspire, in the near future, to the design and development of specific and effective treatments to address the disease.
[EN] The mitochondrion is an organelle of the eukaryotic cell, responsible for energy production and maintenance of cellular homeostasis. However, research carried out over the last twenty years has linked this organelle to situations of cellular disorder and disease. Fibromyalgia is a complex disease of undefined aetiopathogenesis. One of the factors related to its development is oxidative stress. This Final Degree Project has reviewed the main research carried out in the last twenty years that relates mitochondrial dysfunction and oxidative stress to the aetiopathogenesis of FM. Despite the clear evidence of this relationship, there is a need to continue advancing in this field and to aspire, in the near future, to the design and development of specific and effective treatments to address the disease.