Antifolatos como agentes terapeuticos
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2014-07-07
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Jaén: Universidad de Jaén
Resumen
[ES]Se realizó una búsqueda bibliográfica para recoger la información necesaria para el proyecto de propuesta de estudio de nuevos inhibidores de dihidrofolato reductasa. Conclusiones pertinentes de obtuvieron alrededor de su funcionalización y sitios activos con diferentes tipos de inhibidores (como valores de CI50 obtenidos). Se creó una biblioteca de fragmentos para el diseño de nuestros inhibidores. Se procedió a diseñar y sintetizar cuatro moléculas. Y, por último, se ha propuesto como un posible proyecto a realizar, con el cronograma y la propuesta económica.
[EN]Literature search was conducted to collect the necessary information for the proposal project of study of new dihydrofolate reductase inhibitors. Relevant conclusions were obtained about its functionalization and active sites with different types of inhibitors (as IC50 values obtained). It was created a library of fragments for the design of our inhibitors. We proceeded to design and synthesize four molecules. And finally, it was proposed as a possible project to be undertaken, with chronogram and economic proposal.
[EN]Literature search was conducted to collect the necessary information for the proposal project of study of new dihydrofolate reductase inhibitors. Relevant conclusions were obtained about its functionalization and active sites with different types of inhibitors (as IC50 values obtained). It was created a library of fragments for the design of our inhibitors. We proceeded to design and synthesize four molecules. And finally, it was proposed as a possible project to be undertaken, with chronogram and economic proposal.