Diseño de compuestos multidiana de interes para el tratamiento de la enfermedad de Alzheimer
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2024-09-10
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[ES] La Enfermedad del Alzheimer es una de las formas más conocidas y comunes de demencia en todo el mundo, contando en España con cifras superiores a los 800 mil pacientes. Al tratarse de una enfermedad compleja, se cree que su origen puede deberse a muchos factores, desde genéticos hasta cotidianos. Por esta razón, durante estos últimos años, se han estudiado y puesto a prueba varios tratamientos basados en el uso de moléculas multidiana, las cuales pueden actuar en más de una diana a la misma vez.
En el presente trabajo se exponen, a través de varias publicaciones, numerosos ejemplos de moléculas multidiana que se han sintetizado y ensayado recientemente mostrando algunas de ellas resultados prometedores. Además, a lo largo de este trabajo, se proporciona información de vital importancia sobre el diagnóstico y sintomatología de la enfermedad.
[EN] Alzheimer's disease is one of the best known and most common forms of dementia worldwide, with values of more than 800 thousand patients in Spain. As it is a complex disease, it is believed that its origin may be due to many factors, from genetic to everyday factors. For this reason, in recent years, several treatments based on the use of multitarget molecules have been studied and tested, which can act on more than one target at the same time. In the present work, numerous examples of multitarget molecules that have been synthesized and tested recently are presented, showing some of them promising results. In addition, throughout this work, vital information is provided on the diagnosis and symptomatology of the disease.
[EN] Alzheimer's disease is one of the best known and most common forms of dementia worldwide, with values of more than 800 thousand patients in Spain. As it is a complex disease, it is believed that its origin may be due to many factors, from genetic to everyday factors. For this reason, in recent years, several treatments based on the use of multitarget molecules have been studied and tested, which can act on more than one target at the same time. In the present work, numerous examples of multitarget molecules that have been synthesized and tested recently are presented, showing some of them promising results. In addition, throughout this work, vital information is provided on the diagnosis and symptomatology of the disease.