Análisis de la regulación de LncRN As mediada por factores de transcripción cardíacos
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2018-03-16
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Jaén: Universidad de Jaén
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[ES] Existen muchos tipos de RNAs, pero en la última década esta destacando la investigación en el campo de los RNAs de cadena larga no codificantes. Cada día son más los RNAs de cadena larga no codificantes (LncRNAs) que se están descubriendo mediantes técnicas de secuenciación. Día a día se está tratando de avanzar en el conocimiento sobre estos LncRNAs y sobre su relación con los factores de transcripción y sobre el desarrollo del sistema cardiovascular y su participación en enfermedades cardiovasculares. La continua investigación en este campo podría aportar remedios terapéuticos para enfermedades cardíacas. En este proyecto se ha querido analizar la regulación por parte de factores de transcripción cardíacos de los LncRNAs y la implicación que tiene esta regulación a nivel del desarrollo del sistema cardiovascular.
[EN] There are many types of RNAs, but in the last decade they are highlighting research in the field of non-coding long chain RNAs. Moreover non-coding long chain RNAs (LncRNAs) are being discovered each day as they are being discovered by means of sequencing techniques. Day by day we are trying to advance the knowledge about these LncRNAs and their relation with the transcription factors and about the development of the cardiovascular system and its participation in cardiovascular diseases. Continued research in this field could provide therapeutic remedies for heart disease. In this project we wanted to analyze the regulation by cardiac transcription factors of the LncRNAs and the implication that this regulation has at the level of the development of the cardiovascular system.
[EN] There are many types of RNAs, but in the last decade they are highlighting research in the field of non-coding long chain RNAs. Moreover non-coding long chain RNAs (LncRNAs) are being discovered each day as they are being discovered by means of sequencing techniques. Day by day we are trying to advance the knowledge about these LncRNAs and their relation with the transcription factors and about the development of the cardiovascular system and its participation in cardiovascular diseases. Continued research in this field could provide therapeutic remedies for heart disease. In this project we wanted to analyze the regulation by cardiac transcription factors of the LncRNAs and the implication that this regulation has at the level of the development of the cardiovascular system.